FoxP3+RORγt+ T Helper Intermediates Display Suppressive Function against Autoimmune Diabetes
نویسندگان
چکیده
منابع مشابه
FoxP3+RORgammat+ T helper intermediates display suppressive function against autoimmune diabetes.
Recently, traces of double-positive FoxP3(+)RORgammat(+) T cells were identified and viewed as dual programming differentiation intermediates geared toward development into T regulatory or Th17 cells. In this study, we report that FoxP3(+)RORgammat(+) intermediates arise in the NOD mouse T cell repertoire prior to inflammation and can be expanded with tolerogen without further differentiation. ...
متن کاملImpaired Autoimmune T Helper 17 Cell Responses Following DNA Vaccination against Rat Experimental Autoimmune Encephalomyelitis
BACKGROUND We have previously shown that vaccination with DNA encoding the encephalitogenic peptide myelin oligodendrocyte glycoprotein (MOG)(91-108) (pMOG) suppresses MOG(91-108)-induced rat Experimental Autoimmune Encephalomyelitis (EAE), a model for human Multiple Sclerosis (MS). The suppressive effect of pMOG is dependent on inclusion of CpG DNA in the plasmid backbone and is associated wit...
متن کاملThe role of T helper 9(Th9) against Infectious Diseases
Background and aims: Infectious diseases are disorders caused by organisms such as bacteria, viruses, fungi or parasites .The Th9 subset develops in response to combined signals from TGF-b and IL-4 among a cacophony of other cytokines in an extracellular milieu. T helper 9 (Th9) cells, as a novel CD4 T cell subset, seem to play a complex role in the outcome of specific immune responses. In thi...
متن کاملFollicular helper T cells in autoimmune diseases.
Complete List of Authors: Papp, Gábor; University of Debrecen Medical Center, Institute of Medicine, Department of Clinical Immunology Szabó, Krisztina; University of Debrecen Medical Center, Institute of Medicine, Department of Clinical Immunology Szekanecz, Zoltán; University of Debrecen Medical Center, Institute of Medicine, Department of Rheumatology Zeher, Margit; University of Debrecen Me...
متن کاملInterleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice
T cells play a major role in the development of insulin-dependent diabetes mellitus (IDDM) in nonobese diabetic (NOD) mice. Administration of interleukin 12 (IL-12), a key cytokine which guides the development of T helper type 1 (Th1) CD4+ T cells, induces rapid onset of IDDM in NOD, but not in BALB/c mice. Histologically, IL-12 administration induces massive infiltration of lymphoid cells, mos...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2010
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.0903324